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5. Waters Micromass Q-TOF

The Micromass Q-Tof hybrid quadrupole/orthogonal time of flight is a high resolution oa-Tof mass spectrometer that enables automated exact mass measurements in an easy-to-use instrument. The instrument also features a quadrupole mass filter and collision cell for MS/MS analyses. This powerful combination delivers simple exact mass measurement of fragment ions to yield increased confidence in structural elucidation and databank search results.

In the Q-ToF, ions are produced in the electrospray source and transferred to the mass spectrometer via two cones. The ions follow a Z-shaped pathway, while the neutrals and the solvent go straight.

Regulation of source pressure and cone voltages allows tuning desolvation and in-source fragmentation. The first quadrupole can be used as an ion guide (RF only) in MS mode, or as a precursor mass selector for MS/MS.

The ions are collided with argon in the collision hexapole, and the products are analyzed in the time-of-flight (TOF) analyzer. Resolution: ca. 7,000: accuracy: ca. 5 ppm